Larazotide

bulk Larazotide supplier – inquire about high‑purity supply

[ Introduction ]
Larazotide acetate (also known as AT-1001) is a synthetic octapeptide that functions as a tight junction regulator. It was originally derived from the zonula occludens toxin of Vibrio cholerae and works by restoring the normal barrier function of the intestinal epithelium, making it a promising compound in the treatment of gastrointestinal disorders related to increased intestinal permeability.

[ Uses ]
Larazotide is used in research focused on gastrointestinal diseases, especially those involving impaired intestinal barrier function such as celiac disease and inflammatory bowel diseases. It has also been investigated in clinical studies as a potential therapeutic for celiac disease.

[ Specifications ]
Appearance: White to off‑white powder
CAS Number: 258818-34-7
Molecular Formula: C₃₂H₅₅N₉O₁₀
pH Value: Approximately 4.5 in aqueous solution
Solubility: Sparingly soluble in PBS and DMSO; slightly soluble in water
Ingredient: Synthetic octapeptide (Gly-Gly-Val-Leu-Val-Gln-Pro-Gly) acetate salt
Storage: Store at −20 °C; after reconstitution, aliquot and store at −20 °C or −80 °C; avoid repeated freeze-thaw cycles