Ranolazine is metabolized mainly by the CYP3A enzyme. It aswell inhibits addition metabolizing enzyme, cytochrome CYP2D6. For this reason, the doses of ranolazine and drugs that collaborate with those enzymes charge to be adapted if they are used by the aforementioned patient.
Ranolazine should not be used with drugs like ketoconazole, clarithromycin, and nelfinavir that Acetic arrest CYP3A nor with drugs that actuate CYP3A like rifampin and phenobarbital.
For drugs that are abstinent CYP3A inhibitors like diltiazem, verapamil, erythromycin, the dosage of ranolazine should be reduced.
Drugs that are metabolized by CYP2D6 like tricyclic antidepressants may charge to be accustomed at bargain doses if administered with ranolazine.