Phlorizin Properties and Pharmacology
Phlorizin is a white to chicken apparent solid with a melting point of 106–109 °C. It is of candied aftertaste and contains four molecules of baptize in the crystal. Above 200 °C, it decomposes. It is ailing acrid in ether and algid water, but acrid in booze and hot water. Upon abiding acknowledgment to aqueous solutions phlorizin hydrolyzes to phloretin and glucose.
Phlorizin is a aggressive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for bounden to the carrier; this reduces renal glucose transport, blurred the bulk of glucose in the blood. Phlorizin was advised as a abeyant biologic analysis for blazon 2 diabetes, but has back been abolished by added careful and added able constructed analogs, such as canagliflozin and dapagliflozin. Phlorizin is not an able biologic because if orally consumed, it is about absolutely adapted into phloretin by hydrolytic enzymes in the baby intestine.
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