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How cimetidine works

How cimetidine works

At Bolise Co., Ltd., we specialize in providing premium pharmaceutical ingredients to meet the demands of our enterprise partners. Cimetidine, one of our key offerings, is a highly effective histamine H2 receptor antagonist designed to reduce stomach acid production. This product details page explains how cimetidine works, its applications, and why Bolise Co., Ltd. is your reliable source for this essential pharmaceutical ingredient.

What Is Cimetidine?

Cimetidine is a well-established medication used to manage conditions caused by excessive stomach acid, such as gastroesophageal reflux disease (GERD), peptic ulcers, and heartburn. As an H2 receptor antagonist, it targets histamine receptors in the stomach to reduce acid secretion, offering relief and promoting healing in acid-related disorders. Bolise Co., Ltd. supplies cimetidine in various forms, including high-purity powder and tablets, tailored for pharmaceutical manufacturers and distributors.

How Cimetidine Works: The Science Behind Its Efficacy

Understanding how cimetidine works is key to appreciating its value in pharmaceutical formulations. Cimetidine binds competitively to H2 receptors on the basolateral membrane of gastric parietal cells, blocking histamine’s ability to stimulate acid production. This action reduces both basal and stimulated gastric acid secretion, lowering gastric volume and acidity. The result is effective relief from acid-related symptoms and support for the healing of ulcers and esophageal damage. Bolise Co., Ltd. ensures our cimetidine meets rigorous quality standards for consistent performance in your products.

Key Applications of Cimetidine

Cimetidine is a versatile ingredient with a wide range of applications in the pharmaceutical industry. Its primary uses include:

  • Treatment of Peptic Ulcers: Cimetidine promotes the healing of duodenal and gastric ulcers by reducing acid irritation, allowing damaged tissues to recover.
  • Management of GERD: By decreasing acid reflux, cimetidine alleviates heartburn and prevents esophageal damage in patients with gastroesophageal reflux disease.
  • Heartburn Relief: Available in over-the-counter formulations, cimetidine provides fast relief for acid indigestion and sour stomach caused by certain foods or beverages.
  • Specialized Conditions: Cimetidine is used in conditions like Zollinger-Ellison syndrome, where excessive acid production requires robust management.

Bolise Co., Ltd. offers cimetidine in forms suitable for both prescription and OTC products, ensuring flexibility for your manufacturing needs.

Why Choose Cimetidine from Bolise Co., Ltd.?

Bolise Co., Ltd. is committed to delivering pharmaceutical-grade cimetidine that meets the highest industry standards. Here’s why our enterprise clients trust us:

  • Uncompromising Quality: Our cimetidine is produced under strict quality control, ensuring high purity and compliance with USP and international standards.
  • Customizable Forms: We provide cimetidine in various forms, including 200 mg, 300 mg, 400 mg, and 800 mg tablets, as well as bulk powder for custom formulations.
  • Reliable Supply Chain: Our global supply network ensures timely delivery to support your production schedules.
  • Expert Support: Our team offers technical guidance and regulatory support to help you integrate cimetidine into your product lines seamlessly.

Product Specifications

Bolise Co., Ltd. offers cimetidine with the following specifications:

  • Active Ingredient: Cimetidine (USP-grade)
  • Chemical Name: N-cyano-N’-methyl-N’’-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)-guanidine
  • Forms Available: Tablets (200 mg, 300 mg, 400 mg, 800 mg), oral solution (300 mg/5 mL), bulk powder
  • Purity: ≥99%
  • Storage: Store at room temperature (20–25°C), protected from light and moisture
  • Shelf Life: 24 months under proper storage conditions

Our cimetidine is rigorously tested for quality, ensuring it meets the needs of pharmaceutical manufacturers creating both prescription and OTC products.

Dosage and Administration Guidelines

Cimetidine’s dosage varies based on the condition being treated. For enterprise clients formulating products, typical guidelines include:

  • Peptic Ulcers: 800 mg at bedtime or 400 mg twice daily for 4–8 weeks.
  • GERD: 400 mg four times daily or 800 mg twice daily for 4–12 weeks.
  • Heartburn (OTC): 200 mg up to twice daily, taken 30 minutes before meals or drinks that may cause heartburn.
  • Zollinger-Ellison Syndrome: 300–400 mg four times daily, adjustable up to 2.4ntacts, request samples, or obtain a quote. Partner with us to deliver effective, reliable pharmaceutical solutions to your customers.