Retigabine

Unlock neuronal stability with Retigabine — a groundbreaking potassium channel opener designed to support research on neural excitability, ion channel modulation, and anticonvulsant mechanisms.

Product Name: Retigabine

Other Names: Ezogabine; D-23129

Product Introduction: Retigabine is a neuronal potassium channel opener and anticonvulsant compound that modulates KCNQ (Kv7) potassium channels. It enhances the M-current, leading to neuronal hyperpolarization and decreased excitability. Originally approved for the treatment of partial-onset seizures, Retigabine has become a key reference molecule in ion channel and neuropharmacological research due to its unique mechanism of action compared to conventional GABAergic agents.

CAS Number: 150812-12-7

Molecular Formula: C₁₆H₁₈FN₃O₂

Specification: Pharmaceutical or analytical grade; purity ≥98% (HPLC). Stable under normal laboratory conditions when protected from light and moisture.

Appearance: White to off-white crystalline powder

Functions:

1. Adjunctive treatment for partial-onset seizures.
2. Treatment of drug-resistant epilepsy.
3. Relief of neuropathic pain.
4. Management of status epilepticus (SE).
5. Neuroprotective effects.