Polysaccharide-K

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Product Name：Polysaccharide-K

Other Names：PSK, Krestin

Product Introduction：Polysaccharide-K (PSK) is a protein-bound polysaccharide extracted from the mycelium of the medicinal mushroom Trametes versicolor (turkey tail). It has been widely studied and is used in Japan as an approved adjuvant immunotherapy for certain cancers. PSK is known for its immune-modulating and antitumor properties, making it an important natural compound in complementary cancer treatment.

Specification：Protein-bound β-glucan, molecular weight approx. 94–100 kDa, about 38% protein content; saccharide moiety mainly β-glucan with glucose (~75%), plus mannose, xylose, and galactose

Appearance：Light brown to off-white powder

Ingredient：Protein-bound polysaccharide composed of β-glucan chains (β-1,4 backbone with β-1,3 and β-1,6 branches) linked to proteins, with glucose as the major sugar and minor mannose, xylose, and galactose

Functions：
- Immune modulation: Stimulates natural killer cells, T lymphocytes, and macrophages
- Antitumor activity: Promotes apoptosis, inhibits angiogenesis, and reduces metastasis risk
- Adjuvant effects: Enhances chemotherapy and radiotherapy outcomes
- Anti-inflammatory properties: Helps regulate inflammatory and oxidative stress responses
- Antioxidant activity: Contributes to reducing oxidative damage in tissues

Uses：
- Medical: Used as an adjuvant in cancer therapy, especially for gastric, colorectal, and lung cancers
- Dietary supplements: Incorporated into immune-support health products
- Research: Studied for its immunomodulatory and anticancer effects
- Functional foods: Sometimes added to formulations promoting immune health