Description:SAMe is S-Adenosyl-Methionine, a metabolite of the amino acid methionine.SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:
Methylation (contributing methyl groups to activate certain molecules)16,17
The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)18-20
Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)21=23
SAMe occurs naturally in the body; it is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.24 SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.
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