WRW4-NH₂

buy WRW4-NH₂ peptide in bulk from trusted supplier. bulk WRW4-NH₂ supplier inquiry – get free quote today

Product Introduction:

WRW4-NH₂ is a synthetic hexapeptide, consisting of six amino acids with an amidated C-terminus. It is primarily used in inflammation research to block a receptor called FPR2, reducing immune cell overactivity and inflammation. It’s used in experiments, such as studies on infections, diabetes, or brain inflammation, but it’s not a clinical drug.

Main Functions and Benefits：

1. Selective FPR2 antagonism – WRW4-NH₂ potently blocks WKYMVm binding to FPR2 with an IC₅₀ of approximately 0.23 µM, suppressing FPR2-mediated activation pathways.
2. Inhibition of downstream responses – It inhibits intracellular calcium release initiated by agonists such as WKYMVm, MMK1, amyloid β₄₂, and F-peptide, effectively disrupting neutrophil chemotaxis and superoxide generation.
3. Broad anti-inflammatory potential – WRW4-NH₂ has been demonstrated to reduce Brucella proliferation in animal models and protect against ischemia–reperfusion injury by blocking neutrophil infiltration and reactive oxygen species production.

Product Specification：

Solubility：Insoluble in water
Appearance：White to off-white powder