Tolcapone

Enhance neurological research precision with Tolcapone — a reliable COMT inhibitor known for its effectiveness, selectivity, and stable performance in experimental and pharmaceutical applications.
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Product Name: Tolcapone

Other Names: Tasmar; Ro 40-7592

Product Introduction: Tolcapone is a potent and selective catechol-O-methyltransferase (COMT) inhibitor used primarily in the management of Parkinson’s disease. It acts by prolonging the effect of levodopa through inhibition of its peripheral and central metabolism, thereby enhancing dopamine availability. Tolcapone is well recognized for its high efficacy and dual central–peripheral activity, distinguishing it from other COMT inhibitors in both research and clinical settings.

CAS Number: 134308-13-7

Molecular Formula: C₁₄H₁₁NO₅

Specification: Pharmaceutical grade; purity ≥99% (HPLC). Available in standard research quantities. Assay confirmed by chromatographic analysis.

Appearance: Yellow crystalline powder

Ingredient: Active compound — Tolcapone (3,4-dihydroxy-4′-methyl-5-nitrobenzophenone).

Functions: Acts as a reversible COMT inhibitor that reduces the breakdown of levodopa, thereby increasing its plasma half-life and improving dopamine levels in the brain. Commonly applied in neuropharmacological research and Parkinson’s disease treatment studies. It also serves as a reference compound for enzymatic inhibition assays and pharmacokinetic evaluations in drug development.