Sulfaclozine

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[ Introduction ]
Sulfaclozine (also known as sulfachloropyrazine) is a sulfonamide antimicrobial agent used primarily in veterinary medicine. It acts as a competitive inhibitor of para-aminobenzoic acid (PABA), thereby blocking folic acid synthesis in bacteria and protozoa. It is commonly employed to treat coccidiosis and bacterial infections such as fowl cholera, colibacteriosis, infectious coryza, and diarrhea in poultry.

[ Uses ]
- Treatment and control of coccidiosis in poultry (e.g., infection by Eimeria species).
- Management of bacterial infections in birds, including fowl cholera (Pasteurella multocida), colibacteriosis, and Salmonella-associated diseases.
- Utilized in veterinary formulations such as soluble powders for oral administration in drinking water.

[ Specifications ]
Appearance: white to off-white powder
CAS Number: 102-65-8
Molecular Formula: C₁₀H₉ClN₄O₂S
Solubility: Soluble ≥ 29 mg/mL in DMSO (≈101.8 mM); water solubility not detailed for free acid form; sodium salt significantly more soluble (e.g., ≥24.75 mg/mL in H₂O)
Storage: Powder—store at −20 °C (long term) or 0–4 °C (short term); in solution—avoid repeated freeze-thaw; sodium salt may be stored similarly.