SLU-PP-332

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[ Description ]
SLU-PP-332 is a synthetic small-molecule compound that acts as a pan-agonist of estrogen-related receptors (ERRα, ERRβ, and ERRγ), with the strongest potency on ERRα (EC50 = 98 nM).
Known as an "exercise mimetic," it replicates aerobic exercise effects in animal studies (mainly mice) by boosting mitochondrial function, energy expenditure, and fatty acid oxidation; improving endurance; reducing fat buildup; and alleviating metabolic syndrome (e.g., obesity and insulin resistance).

[ Source and Characteristics ]
[ source: ] Synthetic research compound developed for estrogen-related receptor (ERR) activation and metabolic studies.
[ appearance: ] White Powder
[ assay: ] ≥99%
[ CAS: ] 303760-60-3
[ Molecular Formula: ] C₁₈H₁₄N₂O₂

[ Applications ]
1. Exercise mimetic: Activates metabolic pathways typically induced by aerobic exercise, without increasing appetite or actual physical activity.
2. Enhances mitochondrial function: Improves mitochondrial biogenesis, cellular respiration, and energy production in skeletal muscle cells.
3. Promotes fatty acid oxidation and energy expenditure: Increases the use of fat as an energy source, boosting overall energy consumption.
4. Reduces fat accumulation and body weight: In mouse models, it significantly decreases fat mass in obese mice (e.g., 12% body weight loss) and improves metabolic syndrome.
5. Improves endurance and muscle performance: Increases fast-twitch oxidative muscle fibers (Type IIa), enhancing running endurance in mice (up to nearly 50% improvement).
6. Enhances insulin sensitivity and metabolic health: Potential applications in treating obesity, type 2 diabetes, heart failure, and other metabolic diseases.