Retatrutide

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What is Retatrutide?
Retatrutide (LY-3437943) is a synthetic triple-agonist peptide that targets the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). It is being studied for the treatment of obesity and metabolic disorders, showing significant weight loss effects and improved glycemic control in clinical trials.

Product Name：Retatrutide (LY-3437943)
Active Ingredient：Triple agonist peptide for GCGR, GIPR, GLP-1R
Specification ：Purity ≥98% (HPLC)
Color：Off-white to light beige powder
Test Method：HPLC, mass spectrometry, NMR
Solubility：Soluble in water (approx. 30–33 mg/mL with sonication); also soluble in DMSO
CAS No：2381089-83-2
Molecular formula：C₂₂₁H₃₄₂N₄₆O₆₈
Molecular weight：4731 g/mol
Application：Research use in obesity, diabetes, metabolic disorders; potential therapeutic for weight loss and insulin sensitivity improvement
Stability：Stable as lyophilized powder at -20 °C (up to 3 years); less stable in solution, avoid repeated freeze-thaw
Storage Conditions：Store lyophilized powder at -20 °C, protected from moisture and light; for solutions, store at -80 °C

Uses / Applications
Retatrutide is primarily used as a research tool in the study of metabolic diseases, weight management, and diabetes. It is under clinical evaluation as a potential therapeutic agent for obesity and related metabolic disorders.