Protamine

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Introduction

Protamine, typically in the form of protamine sulfate, is a small, strongly basic cationic protein derived from the sperm of salmon or other fish species. It is rich in arginine and is widely used as a heparin antagonist to neutralize the anticoagulant effects of heparin. Protamine sulfate appears as a fine, white or off-white, amorphous or crystalline powder and is commonly available in pharmaceutical and biochemical grades.

Uses

• Heparin Neutralization: Primarily used to reverse the anticoagulant activity of heparin in cases of overdose or after surgical procedures involving heparin.
• Gene Transfer Enhancement: Acts as an alternative to polybrene in retroviral-mediated gene transfer and enhances lipid-mediated transfection efficiency.
• Biochemical Applications: Used for removing DNA from protein samples, purifying DNA-binding proteins, and in complement pathway inhibition studies.
• Other Properties: Exhibits antibacterial properties, inhibits pepsin activity, and can be used in formulations for drug delivery systems.

Specifications

• Appearance: White Powder
• Storage: Store in a cool, dry place, sealed and protected from moisture