Palbociclib

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Introduction

Palbociclib is a selective cyclin-dependent kinase (CDK) 4 and 6 inhibitor that blocks cell cycle progression from the G1 to S phase, leading to cell cycle arrest and inhibition of tumor cell proliferation. It is a targeted therapy compound primarily used in research related to hormone receptor-positive, HER2-negative breast cancer. Palbociclib enhances the efficacy of endocrine therapies and has become an essential molecule in cancer pharmacology studies.

Uses

• Antineoplastic Agent: Used in oncology research to inhibit cancer cell proliferation, particularly in hormone receptor-positive breast cancer models.
• Cell Cycle Research: Applied in biochemical and pharmacological studies to understand CDK-mediated regulation of the cell cycle.

Specifications

• Appearance: White to off-white crystalline powder
• CAS: 571190-30-2
• Molecular Formula: C₂₄H₂₉N₇O₂
• Storage: Store at −20 °C in a tightly sealed container, protected from light and moisture.