Nobiletin

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[ About Nobiletin ]
Nobiletin is a natural flavonoid mainly found in citrus peels, such as dried tangerine peel, orange peel, green tangerine peel, and fingered citron peel. It has multiple methoxy groups, giving it high lipophilicity and significant bioactivity. Nobiletin is usually extracted using ethanol or methanol, followed by chromatographic purification.
It exhibits a range of biological activities, including anti-inflammatory, antioxidant, neuroprotective, anti-cancer effects, and may help improve metabolic health. This makes it valuable in health supplements, pharmaceutical research, and cosmetic products.

[ Basic Information ]
Source: in citrus peels such as orange peel, green tangerine peel, and fingered citron peel.
Extraction Method: Usually extracted with ethanol or methanol solvents followed by chromatographic purification.
Appearance: White Powder
CAS Number: 478-01-3
Chemical Formula: C₂₁H₂₂O₈
Molecular Weight: 402.39 g/mol
Structural Features: Nobiletin is a flavonoid compound with multiple methoxy groups (–OCH₃) in its molecular structure, giving it high lipophilicity and significant bioactivity.

[ Main Activities and Research Directions ]
1.Anti-inflammatory effects: Can inhibit the production of inflammatory mediators such as NO, TNF-α, and IL-6.
2.Antioxidant effects: Scavenges free radicals and protects cells from oxidative stress damage.
3.Anti-tumor effects: Exhibits proliferation inhibition and apoptosis induction in multiple cancer cell models.
4.Neuroprotective effects: May improve symptoms of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
5.Metabolic syndrome improvement: Regulates blood lipids, blood glucose, and insulin sensitivity.

[ Applications ]
1.Health Supplements & Nutraceuticals: Used as a natural antioxidant or anti-inflammatory ingredient.
2.Pharmaceutical Research: Applied in the development of candidate compounds for treating metabolic disorders, tumors, and inflammatory diseases.
3.Cosmetics: Utilized in skincare products for its antioxidant and anti-aging properties.