NNMTi

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Introduction

NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC50 of 1.2 μM. It blocks the methylation of nicotinamide, helping regulate NAD+ levels and methylation balance. Studies show it promotes muscle regeneration, improves function in aged muscles (mimicking exercise benefits), reduces obesity-related issues (weight loss, less fat accumulation, better liver health), and exhibits potential anti-tumor effects. It is a promising preclinical candidate for treating metabolic syndrome and sarcopenia.

Uses

• Biochemical Research: Used to study NNMT-related metabolic pathways and enzyme inhibition mechanisms.
• Pharmaceutical R&D: Applied in early-stage drug discovery and screening research.
• Laboratory Studies: Suitable for controlled in vitro experimental and analytical applications.

Specifications

• Appearance: White to off-white powder
• CAS: 42464-96-0
• Molecular Formula: C₁₀H₁₁IN₂
• Composition: ≥99%
• Storage: Store in a cool, dry place, protected from light and moisture