Nalidixic Acid

Your dependable source for Nalidixic acid with guaranteed quality, purity, and global supply support.

[ Description ]

Nalidixic acid is a synthetic antibacterial agent belonging to the quinolone class. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. It is primarily effective against Gram-negative bacteria and was the first quinolone antibiotic developed for clinical use.

[ Source and Characteristics ]

• [ source: ] Synthetic antibacterial compound (quinolone class)
• [ appearance: ] White to pale yellow crystalline powder
• [ CAS: ] 389-08-2
• [ Molecular Formula: ] C₁₂H₁₂N₂O₃

[ Applications ]

1. Treatment of urinary tract infections caused by susceptible Gram-negative bacteria such as Escherichia coli, Klebsiella, and Proteus species.
2. Occasionally used in laboratory research to study bacterial DNA replication and quinolone resistance mechanisms.
3. Basis compound for the development of later-generation quinolone and fluoroquinolone antibiotics.
4. May be used in veterinary medicine for bacterial infections in certain animals under professional supervision.
5. Historical reference compound for understanding DNA gyrase inhibition and antibacterial pharmacology.