Methoxylamine Hydrochloride

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[ Introduction ]

Methoxylamine Hydrochloride, also known as O-Methylhydroxylamine Hydrochloride, is a white crystalline powder widely utilized as a chemical intermediate in the synthesis of pharmaceuticals, pesticides, and dyes. It is the hydrochloride salt of methoxyamine, valued for its reactivity in forming O-methyl oximes from aldehydes and ketones. This compound is essential in organic chemistry and has applications in medical research for inhibiting DNA repair processes.

[ Uses ]

Methoxylamine Hydrochloride is a key reagent in organic synthesis, primarily for preparing O-methyl oximes used in pharmaceutical intermediates, such as second-generation cephalosporin antibiotics (e.g., cefuroxime) and hydroxyurea. It is also employed in the production of low-toxicity pesticides like kresoxim-methyl in the agricultural sector. Additionally, it serves in color photography, film development, and as an internal standard in prostaglandin assays via gas chromatography-mass spectrometry.

[ Specifications ]

Appearance: White to almost white crystalline powder

CAS Number: 593-56-6

Molecular Formula: CH5NO·ClH

pH Value: Approximately 2–4 in a 1% aqueous solution

Solubility: Highly soluble in water, soluble in alcohol, insoluble in ether and toluene

Ingredient: Methoxylamine Hydrochloride (purity typically ≥98% for synthesis-grade)

Storage: Store at room temperature in a dry, well-ventilated area; protect from moisture due to hygroscopic nature

[ Precautions ]

Methoxylamine Hydrochloride is corrosive and harmful if swallowed, inhaled, or in contact with skin, causing severe burns and eye damage. Use protective gloves, clothing, and eye protection, and avoid inhalation of dust or vapors. Do not mix with strong oxidizers or bases to prevent hazardous reactions. Always refer to the Safety Data Sheet (SDS) for detailed handling and ensure adequate ventilation during use.