Kasugamycin

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Product Name: Kasugamycin

Other Names: Kasumin, 3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol

CAS No.: 6980-18-3 (free base), 19408-46-9 (hydrochloride)

Molecular Formula: C₁₄H₂₅N₃O₉ (free base)

Specification: Purity ≥ 98%, available as a white to off-white crystalline powder, complies with agricultural standards

Appearance and Color: White to off-white crystalline powder

Ingredient Information: Kasugamycin is an aminoglycoside antibiotic from Streptomyces kasugaensis, made by fermentation and purification, often as a stable hydrochloride salt. It has carbon, hydrogen, nitrogen, and oxygen, with a D-chiro-inositol and hexopyranosyl sugar structure. It’s a water-soluble powder (1000 g/L at 20°C), low-toxicity to mammals (LD50 > 4000 mg/kg in rats).

Uses: Widely used in agriculture as a bactericide and fungicide to control diseases like rice blast (Magnaporthe oryzae) and bacterial leaf spot, applied at 20-40 ppm, with over 10,000 tons used annually in Asia. It is also employed in research for studying protein synthesis inhibition in bacteria and fungi, targeting the 30S ribosomal subunit, with minimal resistance development due to its unique structure. Additionally, it finds application in plant pathology for protecting crops like apples and pears from fire blight (Erwinia amylovora), approved in the US since 2018, though restricted in some regions due to environmental concerns.