Icatibant

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[ Introduction ]
Icatibant (brand name Firazyr) is a synthetic decapeptide peptidomimetic that specifically and competitively antagonizes the bradykinin B₂ receptor. It is primarily used for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency.
[ Uses ]
Icatibant is indicated for the treatment of acute hereditary angioedema attacks in adults. It rapidly inhibits bradykinin-mediated vascular permeability and swelling, providing effective relief during HAE episodes.
[ Specifications ]
Appearance: White liquid
CAS Number: 130308-48-4
Molecular Formula: C59H89N19O13S
Solubility: Water solubility ~0.057 g/L
Ingredient: Icatibant acetate with excipients such as glacial acetic acid, sodium hydroxide, sodium chloride, and water for injection
Storage: Store sealed in a dry place at 2–8 °C under refrigeration, preferably under inert atmosphere
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