FOXO4-DRI

Purchase FOXO4-DRI Online From Manufacturer/Supplier. Get Latest Price - Bolise Co., Ltd.

Product Name: FOXO4-DRI

Other Names: FOXO4 D-Retro-Inverso peptide; FOXO4-/FOXO4-DRI; D-Retro-Inverso FOXO4

Product Introduction: A synthetic D-amino-acid peptide engineered to disrupt the FOXO4–p53 interaction, FOXO4-DRI selectively induces apoptosis in senescent cells. It has demonstrated the ability to restore tissue homeostasis, reverse age-associated dysfunction, and improve organ health in preclinical models.

CAS Number: 2460055-10-9

Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄

Specification: Purity ≥ 95–99%; Molecular Weight 5358 g/mol; typically supplied as the TFA salt; storage recommended at –20 °C or –80 °C for long-term stability.

Appearance: White to off-white powder

Ingredient: Synthetic D-retro-inverso peptide based on the FOXO4 sequence, comprising 46 D-amino acid residues

Functions: Acts as a senolytic by interfering with the FOXO4–p53 binding in senescent cells, leading to p53 nuclear exclusion and caspase-dependent apoptosis. Proven to eliminate senescent fibroblasts and Leydig cells in vitro and in aged mice, thereby improving tissue function and reducing markers of aging and inflammation.