Conopeptide

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Introduction

Conopeptides are a diverse group of bioactive peptides found in the venom of marine cone snails (genus Conus). These peptides, often referred to as conotoxins when rich in disulfide bonds, are produced by the snails to capture prey and defend against predators. Known for their high specificity and potency in targeting ion channels, receptors, and transporters in the nervous system, conopeptides have significant potential in pharmaceutical research, particularly for developing analgesics and neurological treatments.

Uses

• Acts as a potent analgesic, with some conopeptides (e.g., ziconotide) approved for severe pain management.
• Serves as a research tool in neuroscience to study ion channel and receptor functions.
• Targets specific neurological disorders, such as epilepsy and depression, through selective interaction with neural pathways.
• Provides potential antimicrobial activity against bacteria and fungi, expanding therapeutic applications.
• Supports drug development for conditions like myocardial infarction due to its precise molecular targeting.

Specifications

• Appearance: Typically a white or off-white powder when isolated.
• Ingredient: Peptides consisting of 10–40 amino acids, often with multiple disulfide bonds; may include post-translational modifications like hydroxylation or glycosylation.
• Storage: Store at -20°C in a dry, airtight container, protected from light and moisture to maintain stability.

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