Candicidin

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[ Introduction ]
Candicidin, a polyene macrolide antifungal from Streptomyces griseus discovered in 1953, effectively targets Candida albicans and other fungi. It works by binding ergosterol in fungal cell membranes, disrupting them and causing cell death. Widely used in topical treatments for vulvovaginal candidiasis, it is valued for its strong antifungal properties without hormonal effects.

[ Uses ]
Candicidin is primarily used topically to treat vulvovaginal candidiasis caused by Candida species, offering reliable relief from fungal infections. It also shows potential in agricultural biocontrol, with certain isomers effective against soilborne fungal diseases like Rhizoctonia rot in cucumbers.

[ Specifications ]
Appearance: Yellow to yellowish-brown powder
CAS Number: 1403-17-4
Molecular Formula: C59H84N2O18
pH Value: Neutral to slightly acidic (no specific pH data; typically neutral in organic solvents)
Solubility: Insoluble in water; soluble in ethanol, methanol, and dimethyl sulfoxide (DMSO)
Ingredient: Candicidin complex (mainly candicidin D, with A1 and A3 analogues)
Storage: Keep at -20°C in a sealed container, protected from light and moisture to ensure stability