B7-33

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[ Introduction ]
B7-33 is a synthetic single-chain peptide designed as a simplified analogue of human relaxin-2. Unlike native relaxin, B7-33 maintains biological activity through selective activation of relaxin family peptide receptor 1 (RXFP1) while offering greater stability and easier synthesis. It is under research for its anti-fibrotic, cardioprotective, and anti-inflammatory properties.
[ Uses ]
B7-33 is primarily studied in preclinical models for cardiovascular protection, reduction of fibrosis, and modulation of inflammatory pathways. It has shown promise in attenuating myocardial infarction damage, limiting cardiac remodeling, and reducing organ fibrosis, while minimizing the risk of hypotension commonly associated with native relaxin.
[ Specifications ]
Appearance: White to off-white powder
pH Value: Neutral in aqueous solutions
Solubility: Water-soluble; compatible with physiological buffers
Ingredient: Synthetic peptide analogue of human relaxin-2 (single-chain B-domain fragment)
Storage: Store at −20 °C or below; protect from light and moisture; avoid repeated freeze–thaw cycles
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