AICAR

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[ Introduction ]
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a purine biosynthesis intermediate and a well-known AMP-activated protein kinase (AMPK) activator, commonly used in metabolic and cellular energy research.

[ Uses ]
AICAR is primarily applied in research to activate AMPK in cell and animal models, supporting studies on diabetes, cardiovascular protection, obesity, and energy metabolism. It has also been investigated for its protective role in ischemic conditions and potential in oncology research.

[ Specifications ]
Appearance: White to off-white crystalline powder
CAS Number: 3031-94-5
Molecular Formula: C₉H₁₅N₄O₈P
pH Value: ~7.0 in aqueous solution
Solubility: Soluble in water (~19 mg/mL) and DMSO
Ingredient: 5-Aminoimidazole-4-carboxamide ribonucleoside, purity ≥99% (HPLC)
Storage: Store at −20 °C, protect from moisture, avoid repeated freeze–thaw cycles

[ Precautions ]
For research use only, not intended for human or veterinary use. Handle with gloves, protective clothing, and eye protection. Avoid inhalation and direct skin contact. Prepare fresh solutions when possible, and dispose of waste according to local regulations.