Acotiamide

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Product Name: Acotiamide
CAS No.: 185106‑16‑5
Molecular Formula: C₂₁H₃₀N₄O₅S
Molecular Weight: 450.55
Appearance: white to off‑white powder

Uses: Acotiamide is used as an orally active gastrointestinal prokinetic agent and selective, reversible acetylcholinesterase inhibitor. It is approved in Japan (tradename Acofide) and Russia for treatment of functional dyspepsia—especially symptoms including postprandial fullness, early satiety, and upper abdominal bloating. It works by increasing acetylcholine levels in the digestive tract to enhance gastric motility and accelerate gastric emptying.

Product Introduction: Acotiamide (also known as YM‑443 or Z‑338) is a small‑molecule therapeutic with a thiazole‑carboxamide core. It was first approved in Japan around 2013 for functional dyspepsia. The drug is administered orally, typically at 100 mg three times daily before meals, and has a half‑life ranging from approximately 10.9 to 21.7 hours, with high protein binding (≈84–86 %) and elimination largely via feces (≈93 %) and minor renal excretion (≈5 %). Clinical trials have demonstrated significant symptom improvement in functional dyspepsia patients, particularly for bloating and early satiety.