ACE-031

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[ Description ]

ACE-031 (also known as Ramatercept) is a recombinant fusion protein developed as a soluble decoy form of the activin receptor type IIB (ActRIIB). It binds to myostatin and related ligands that inhibit muscle growth, thereby blocking negative signaling and promoting muscle hypertrophy.

[ Source and Characteristics ]

[ source: ] Produced by recombinant DNA technology as a fusion of the extracellular domain of ActRIIB with the Fc region of human IgG1.
[ appearance: ] white to off-white sterile powder for reconstitution.
[ Purity: ] ≥95%
[ CAS: ] 1621169-52-5
[ Molecular Formula: ] C₁₃₃H₂₂₇N₄₃O₃₃

[ Main Components ]

- Extracellular ligand-binding domain of human activin receptor type IIB (ActRIIB).
- Fc (constant) region of human IgG1 immunoglobulin.
- Linker regions and glycosylation sites characteristic of the fusion protein structure.

[ Applications ]

1. Investigational therapy for Duchenne Muscular Dystrophy (DMD) to enhance muscle mass and strength.
2. Potential treatment for muscle wasting (cachexia) associated with chronic diseases.
3. Research tool in studies of myostatin and TGF-β pathway regulation in muscle development.
4. Exploration in bone metabolism and improvement of bone density in preclinical and clinical research.
5. Pharmacodynamic studies in healthy volunteers to evaluate safety, tolerability, and effects on lean body mass.
6. Known misuse as a doping substance in sports due to its muscle-enhancing potential.