Acacetin

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Introduction

Acacetin is a naturally occurring flavonoid compound found in several plant species. It is commonly used as a reference standard and research material in pharmaceutical, biochemical, and life science studies due to its well-defined molecular structure and high stability.

Uses

• Anti-inflammatory effects: Inhibits inflammatory factor release and NF-κB/MAPK pathways, alleviating inflammation-related diseases.
• Antioxidant effects: Scavenges reactive oxygen species (ROS), activates Nrf2 pathway, protecting cells from oxidative stress damage.
• Anticancer effects: Induces cancer cell apoptosis, autophagy, and cell cycle arrest; inhibits tumor growth (e.g., prostate cancer, liver cancer).
• Cardiovascular protective effects: Anti-arrhythmic (especially atrial fibrillation), improves endothelial function, reduces atherosclerosis and myocardial ischemia-reperfusion injury.
• Neuroprotective effects: Inhibits neuroinflammation, with potential for treating Alzheimer's disease and cerebral ischemic injury.
• Anti-infective effects: Antiviral, antibacterial, and antiparasitic (e.g., against Plasmodium).
• Anti-diabetic effects: Promotes glucose uptake and improves insulin resistance.
• Hepatoprotective effects: Reduces liver injury, fibrosis, and fatty liver.
• Other effects: Anti-obesity, immunomodulatory, analgesic, antipyretic, and anti-aging.

Specifications

• Appearance: Yellowish-brown Power
• Sources: Found in plants such as chrysanthemum (Chrysanthemum spp.), black locust flowers (Robinia pseudoacacia), snow lotus (Saussurea involucrata), Buddleja officinalis (denseflower buddleja), and others. It often exists in the form of acaciin (acacetin glycosides).
• CAS: 480-44-4
• Molecular Formula: C₁₆H₁₂O₅
• Composition: Acacetin ≥98%
• Storage: Store in a cool, dry place, sealed and protected from light