Eribulin

Discover high-purity Eribulin Powder — a synthetic microtubule-targeting antineoplastic compound ideal for oncology research and pharmaceutical applications.

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Introduction

Eribulin is a synthetic macrocyclic ketone analogue of the marine-derived natural product Halichondrin B. It inhibits microtubule dynamics by binding to tubulin, preventing microtubule polymerization, and sequestering tubulin into non-productive aggregates. This disruption of the mitotic spindle causes G₂/M cell-cycle arrest and induces apoptosis in tumor cells. Eribulin has demonstrated significant antitumor activity, particularly in metastatic breast cancer and liposarcoma.

Uses

• Antineoplastic Agent: Used for the treatment of metastatic breast cancer and liposarcoma after prior chemotherapy, leveraging its unique mechanism against microtubule dynamics.

Specifications

• Appearance: White to off-white powder
• CAS: 253128-41-5
• Molecular Formula: C₄₀H₅₉NO₁₁
• Storage: Store at −20 °C, protect from light; prepare stock solutions in suitable solvent and limit freeze-thaw cycles.