Nonapeptide-1

Product Description

Nonapeptide-1 is a synthetic biomimetic peptide designed to inhibit melanin production, making it a highly effective skin-lightening agent in cosmetic formulations. Comprising nine amino acids, it acts as a potent α-Melanocyte-Stimulating Hormone (α-MSH) antagonist, with an IC50 of 11 nM. Its primary advantage lies in its ability to interfere with tyrosinase activity in melanocytes, reducing hyperpigmentation and lightening sunspots or darkened skin areas caused by sun exposure, pregnancy, or conditions like diabetes or Addison’s disease. Nonapeptide-1 is widely used in skincare products such as serums, creams, and lotions for its whitening and spot-removing properties. At a concentration of 200 µg/mL, it fully inhibits melanin synthesis in fungi, while at 100 µM, it reduces melanin content in melanocytes by 27-43%. Recommended dosage in formulations is 0.5-3%, offering a safe and efficient solution for achieving even skin tone.

Product Specification

• INCI Name: Nonapeptide-1
• Chemical Name: L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide
• CAS Number: 158563-45-2
• Molecular Formula: C61H87N15O9S
• Appearance: White to off-white powder
• Solubility: Soluble in water and polar solvents like ethanol; insoluble in non-polar solvents
• Stability: Stable under standard storage conditions (cool, dry place); avoid prolonged exposure to heat and light
• Properties: Inhibits tyrosinase activity, reduces melanin synthesis by 27-43% at 100 µM, non-toxic, suitable for cosmetic use