Calmnerv CR

Product Description

Calmnerv CR is a plant-based cosmetic active derived from tangerine (Citrus reticulata) fruit, developed using a unique extraction method that maintains a natural 1:1 ratio of flavonoids to alkaloids. It functions by inhibiting the TRPV1 ion channel, effectively reducing calcium ion influx and soothing discomfort such as stinging, burning, or itching. Calmnerv CR is widely used in sensitive skin formulations to enhance tolerance against irritants like acids, retinoids, and exfoliants. Clinically proven at 0.5% to significantly reduce lactic acid-induced irritation within 7 days, this active is ideal for daily care of sensitive or reactive skin.

Product Specification

• Product Name: Calmnerv CR
• INCI Ingredients: Water (Aqua), Butylene Glycol, Citrus Reticulata (Tangerine) Fruit Extract
• Appearance: Yellow to brownish-yellow liquid
• Solubility: Water-soluble (with organic solvents)
• Stability: Stable under cool, dark storage (≤30 °C); shelf life 24 months
• Efficacy: Relieves skin discomfort such as stinging, itching, and burning sensations. Its mechanism involves inhibiting TRPV1 activation, reducing calcium ion influx, and enhancing skin comfort and tolerance.

Recommended Usage & Applications

• Usage Level: 0.5% – 2.0%
• Application: Creams, lotions, serums, cleansers, sunscreens, post-procedure care
• Processing: Recommended to add below 45 °C