PE-22-28

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[ Description ]
PE-22-28 is a synthetic peptide derived from a shortened analog of spadin. It functions as a potent antagonist of the TREK-1 potassium channel and is being studied for its antidepressant, neuroactive, and neuroprotective properties.

[ Source and Characteristics ]
[ appearance: ] white to off-white powder for reconstitution.
[ CAS: ] N/A
[ Molecular Weight: ] 833.9 g/mol
[ Molecular Formula: ] C₃₇H₅₉N₁₁O₁₁

[ Main Components ]
- Heptapeptide sequence: GVSWGLR.
- High-purity peptide (≥95%) with specific structure optimized for TREK-1 channel inhibition.

[ Applications ]
1. Used as an antagonist of TREK-1 potassium channels.
2. Investigated as a potential antidepressant compound.
3. Promotes neurogenesis and synaptogenesis in preclinical studies.
4. Studied for neuroprotection and cognitive recovery in brain injury models.
5. Experimental use in research on neuronal plasticity and neurodegenerative diseases.
6. Tool compound in ion channel and neuroscience pharmacology research.