Anticapsin

Product description:Anticapsin is a new fermentation product which inhibits formation of the hyaluronic acid capsule of Streptococcus pyogenes. Production of this metabolite in a complex medium is enhanced by high levels of carbohydrate. A number of carbon sources support biosynthesis but sucrose is most effective, the optimum level being 150 g/liter. Neither glucose nor fructose, alone or in combination, serves as an equivalent substitute for sucrose. The addition of dibasic potassium phosphate to the medium further increases anticapsin production. Dissolved oxygen levels are important for synthesis and stability of the metabolite. Anticapsular activity diminishes rapidly in previously aerated broths which are held under static conditions. This decrease does not occur in pasteurized broths or unpasteurized filtrates.
CAS No.: 28978-07-6 
Synonyms: anticapsin;(1R,6R,αS)-α-Amino-5-oxo-7-oxabicyclo[4.1.0]heptane-2β-propionic acid 
Molecular formular: C9H13NO4 
Molecular weight: 199.205 
MOL file: 28978-07-6.mol